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Flagellin Redundancy in Caulobacter crescentus and Its Implications for Flagellar Filament Assembly

Lookup NU author(s): Alex Faulds-Pain, Christopher Birchall, Christine Aldridge, Dr Wendy Smith, Giulia Grimaldi, Dr Joseph Gray, Dr Phillip Aldridge

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Abstract

Bacterial flagella play key roles in surface attachment and host-bacterial interactions as well as driving motility. Here, we have investigated the ability of Caulobacter crescentus to assemble its flagellar filament from six flagellins: FljJ, FljK, FljL, FljM, FljN, and FljO. Flagellin gene deletion combinations exhibited a range of phenotypes from no motility or impaired motility to full motility. Characterization of the mutant collection showed the following: (i) that there is no strict requirement for any one of the six flagellins to assemble a filament; (ii) that there is a correlation between slower swimming speeds and shorter filament lengths in Delta fljK Delta fljM mutants; (iii) that the flagellins FljM to FljO are less stable than FljJ to FljL; and (iv) that the flagellins FljK, FljL, FljM, FljN, and FljO alone are able to assemble a filament.


Publication metadata

Author(s): Faulds-Pain A, Birchall C, Aldridge C, Smith WD, Grimaldi G, Nakamura S, Miyata T, Gray J, Li GL, Tang JX, Namba K, Minamino T, Aldridge PD

Publication type: Article

Publication status: Published

Journal: Journal of Bacteriology

Year: 2011

Volume: 193

Issue: 11

Pages: 2695-2707

Print publication date: 25/03/2011

ISSN (print): 0021-9193

ISSN (electronic): 1098-5530

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/JB.01172-10

DOI: 10.1128/JB.01172-10


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