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Hypertrophic cardiomyopathy and transposition of great arteries associated with maternal diabetes and presumed gestational diabetes

Lookup NU author(s): Dr Malcolm Brodlie

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Abstract

Maternal diabetes mellitus affects the foetal heart both structurally and functionally. In early gestation, it has a teratogenic effect causing defects of primary cardiogenesis. In late gestation, it causes a unique form of hypertrophic cardiomyopathy. We report an infant of a diabetic mother and an infant where there was presumed gestational diabetes during the pregnancy who presented with combined severe hypertrophic cardiomyopathy and complex transposition of the great arteries. This rare combination of structural and functional cardiac abnormalities reflects the different mechanisms and timings of injury that may occur to the foetal heart in association with maternal diabetes and has not been previously reported. The combination has significant implications regarding medical and surgical management, and necessitates prolonged supportive therapy whilst awaiting regression of the hypertrophic cardiomyopathy followed by delayed arterial switch operation.Conclusion: We describe two infants with the unusual combination of both hypertrophic cardiomyopathy and transposition of the great arteries. One was an infant of a diabetic mother, and the second was associated with presumed gestational diabetes.


Publication metadata

Author(s): Chaudhari M, Brodlie M, Hasan A

Publication type: Article

Publication status: Published

Journal: Acta Paediatrica, International Journal of Paediatrics

Year: 2008

Volume: 97

Issue: 12

Pages: 1755-1757

ISSN (print): 0803-5253

ISSN (electronic): 1651-2227

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1651-2227.2008.01022.x

DOI: 10.1111/j.1651-2227.2008.01022.x


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