Lookup NU author(s): Dr Olivier Joly
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Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current MRI approaches are still limited to localize brainstem and basal ganglia nuclei accurately. By combining ultra-high resolution structural MRI and contrast-enhanced MRI using iron oxide nanoparticles at high field (3 T and 7 T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.
Author(s): Tani N, Joly O, Iwamuro H, Uhrig L, Wiggins CJ, Poupon C, Kolster H, Vanduffel W, LeBihan D, Palfi S, Jarraya B
Publication type: Article
Publication status: Published
Print publication date: 16/06/2011
ISSN (print): 1053-8119
ISSN (electronic): 1095-9572
Publisher: Academic Press
PubMed id: 21704174
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