Browse by author
Lookup NU author(s): Don Jayamanne, Mary Bythell, Dr Martin Ward Platt, Professor Judith Rankin
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Purpose: We describe the prevalence, associated anomalies, prenatal diagnosis and survival of patients with bladder exstrophy-epispadias complex. Materials and Methods: Data were extracted from the Northern Congenital Abnormality Survey for patients delivered during 1985 to 2008. This survey collects data on congenital anomalies in fetuses, stillbirths and live-born infants of mothers residing in Northern England (Northumberland, North Cumbria, Tyne and Wear Durham, Darlington and Teesside). Results: A total of 43 cases were identified from 824,368 registered births for a total prevalence of 5.22 per 100,000 (95% CI 3.77-7.03). Excluding 1 twin with cloacal exstrophy, 42 cases occurred in singleton pregnancies. A total of 29 cases (69%) were isolated and 13 (31%) were associated with other anomalies, of which 11 (26%) were other structural and 2 (5%) were chromosomal. Male-to-female ratio was 2.2: 1 for all singleton cases and 1.4: 1 for isolated cases. Total prevalence of bladder exstrophy-epispadias complex singleton cases was 5.10 per 100,000 registered births (95% CI 3.67-6.89) and overall live birth prevalence was 4.63 per 100,000 live births (95% CI 3.28-6.36). Total prevalence of isolated cases of bladder exstrophy-epispadias complex was 3.52 per 100,000 births (95% CI 2.365.05) and live birth prevalence was 3.29 per 100,000 (95% CI 2.17-4.79). Accuracy of prenatal diagnosis was low, with 4 cases (10%) being detected prenatally by routine ultrasound (bladder exstrophy in 3, cloacal exstrophy in 1). Overall survival of all infants at 1 year was 95%. Conclusions: This population based study demonstrates a prevalence rate similar to other studies, a low prenatal diagnosis rate and high survival.
Author(s): Jayachandran D, Bythell M, Platt MW, Rankin J
Publication type: Article
Publication status: Published
Journal: Journal of Urology
Year: 2011
Volume: 186
Issue: 5
Pages: 2056-2060
Print publication date: 01/11/2011
ISSN (print): 0022-5347
ISSN (electronic): 1527-3792
Publisher: Elsevier Inc.
URL: http://dx.doi.org/10.1016/j.juro.2011.07.022
DOI: 10.1016/j.juro.2011.07.022
Altmetrics provided by Altmetric
