Toggle Main Menu Toggle Search

Open Access padlockePrints

Neurogenic Marker Abnormalities in the Hippocampus in Dementia with Lewy Bodies

Lookup NU author(s): Mary Johnson, Dr Clive Ballard, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Dementia with Lewy bodies (DLB) is associated with alpha synuclein pathology and slowly progressive dementia. Progenitor abnormalities have previously been reported in the subventricular zone (SVZ) adjacent to the lateral ventricle. To evaluate changes in neural stem cells and progenitors in the hippocampal neurogenic niche, immunohistochemistry (IHC) using the neural stem cell markers Musashi 1, nestin, proliferating cell nuclear antigen (PCNA), doublecortin, and glial fibrillary acidic protein (GFAP) were examined in age-matched control and DLB groups. Staining was quantified in the hippocampal SVZ, subgranular layer (SGL) and ependymal cell layer (EPL). There was a significant loss in DLB of Musashi 1 (P < 0.01) in all areas, an increase in PCNA in hippocampal SVZ (P = 0.01) and SGL (P = 0.05), and an increase in doublecortin in the hippocampal SVZ (P = 0.04) and EPL (P = 0.02). This is the first report of the changes in neurogenic markers in the hippocampal SVZ and EPL in DLB and may offer the potential for understanding disease pathology and in the devising of treatment. (C) 2010 Wiley-Liss, Inc.


Publication metadata

Author(s): Johnson M, Ekonomou A, Hobbs C, Ballard CG, Perry RH, Perry EK

Publication type: Article

Publication status: Published

Journal: Hippocampus

Year: 2011

Volume: 21

Issue: 10

Pages: 1126-1136

Print publication date: 27/07/2010

ISSN (print): 1050-9631

ISSN (electronic): 1098-1063

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/hipo.20826

DOI: 10.1002/hipo.20826


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share