Lookup NU author(s): Professor Zofia Chrzanowska-Lightowlers,
Professor Robert Lightowlers
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All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.
Author(s): Chrzanowska-Lightowlers ZMA, Pajak A, Lightowlers RN
Publication type: Review
Publication status: Published
Journal: Journal of Biological Chemistry
Print publication date: 26/08/2011
ISSN (print): 0021-9258
ISSN (electronic): 1083-351X
Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC