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The development of nanoparticulate materials for biodegradable bone fracture fixation plates: (I)

Lookup NU author(s): Dr Marcia Clark

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Abstract

A cost effective route for the production of nanoparticulate calcium carbonate with high phase purity, a narrow particle size range and low tendency for agglomeration represents a crucial stage in the development of degradable nanocomposite materials for the manufacture of fracture fixation plates. In this study, the size, morphology and zeta potential of calcium carbonate (CaCO₃) precipitated through carbonation of an aqueous solution of calcium hydroxide were investigated experimentally. It was found that the precipitating temperature, pH and the addition of a chelating agent were most influential in producing nanoparticulate CaCO₃. The smallest particles (mean of 48 nm) were produced with an initial temperature of −93°C, initial pH of 8.5 and EDTA added. This route also has the advantage of narrow particle size distributions, which together with a zeta potential greater than 30 mV means that the precipitated CaCO₃ is well suited for use as a filler in a biodegradable nanocomposite as indicated above.

Publication metadata

Author(s): Clark ME, Farrar DF, Walker G, Scotchford CA, Grant DM

Publication type: Article

Publication status: Published

Journal: International Journal of Nano and Biomaterials

Year: 2008

Volume: 1

Issue: 3

Pages: 203-221

ISSN (print): 1752-8933

ISSN (electronic): 1752-8941

Publisher: Inderscience Publishers

URL: http://dx.doi.org/10.1504/IJNBM.2008.016871

DOI: 10.1504/IJNBM.2008.016871

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