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A widespread family of bacterial cell wall assembly proteins

Lookup NU author(s): Dr Yoshikazu Kawai, Dr Jon Marles-Wright, Dr Robert Cleverley, Dr Robyn Emmins, Nadja Heinz, Dr Nhat Khai Bui, Christopher Hoyland, Professor Rick Lewis, Professor Waldemar Vollmer, Dr Richard Daniel, Professor Jeff Errington

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Abstract

Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall. The EMBO Journal (2011) 30, 4931-4941. doi: 10.1038/emboj.2011.358; Published online 30 September 2011


Publication metadata

Author(s): Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S, Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ, Vollmer W, Daniel RA, Errington J

Publication type: Article

Publication status: Published

Journal: EMBO Journal

Year: 2011

Volume: 30

Issue: 24

Pages: 4931-4941

Print publication date: 01/12/2011

ISSN (print): 0261-4189

ISSN (electronic): 1460-2075

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/emboj.2011.358

DOI: 10.1038/emboj.2011.358


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