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Lookup NU author(s): Dr Yoshikazu Kawai, Dr Jon Marles-WrightORCiD, Dr Robert Cleverley, Dr Robyn Emmins, Nadja Heinz, Dr Nhat Khai Bui, Christopher Hoyland, Professor Rick Lewis, Professor Waldemar Vollmer, Dr Richard DanielORCiD, Professor Jeff ErringtonORCiD
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Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall. The EMBO Journal (2011) 30, 4931-4941. doi: 10.1038/emboj.2011.358; Published online 30 September 2011
Author(s): Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S, Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ, Vollmer W, Daniel RA, Errington J
Publication type: Article
Publication status: Published
Journal: EMBO Journal
Year: 2011
Volume: 30
Issue: 24
Pages: 4931-4941
Print publication date: 01/12/2011
ISSN (print): 0261-4189
ISSN (electronic): 1460-2075
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1038/emboj.2011.358
DOI: 10.1038/emboj.2011.358
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