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Common variation in the adiponectin gene has an effect on systolic blood pressure

Lookup NU author(s): Dr Peter Avery, Dr Sheila Patel, Dr Ibrahim Ibrahim, Professor Mark Walker, Professor Bernard Keavney

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Abstract

The genotype at the C-11377G single-nucleotide polymorphism (SNP) (rs266729) in the adiponectin gene promoter has been shown to affect the prevalence of coronary atherosclerosis and incidence of vascular events in men, and to affect carotid intima media thickness. We have examined the relationship between this polymorphism and blood pressure in a cohort ascertained to express variability in blood pressure measurements. We studied a cohort of 255 families comprising 1425 individuals ascertained via a hypertensive proband. Blood pressure was measured by ambulatory monitoring. The C-11377G SNP was genotyped using a TaqMan assay. There was evidence of association between this SNP and log systolic blood pressure (SBP), having adjusted for significant covariates including gender, age and drug treatment; P=0.009, 0.014 and 0.022, respectively, for daytime, night-time and clinic measurements. Replacing C by G caused an increase of 1.63, 1.83 and 1.61%, respectively, per gene copy. There were smaller effects on diastolic blood pressure and waist-hip ratio, which were of borderline significance. Genotype at the C-11377G (rs266729) polymorphism has independent effects both on waist-hip ratio and SBP. This may help in understanding the complex role that the adiponectin gene has in atherosclerosis. Journal of Human Hypertension (2011) 25, 719-724; doi:10.1038/jhh.2010.122; published online 20 January 2011


Publication metadata

Author(s): Avery PJ, Patel SK, Ibrahim IM, Walker M, Keavney BD

Publication type: Article

Publication status: Published

Journal: Journal of Human Hypertension

Year: 2011

Volume: 25

Issue: 12

Pages: 719-724

Print publication date: 01/12/2011

ISSN (print): 0950-9240

ISSN (electronic): 1476-5527

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/jhh.2010.122

DOI: 10.1038/jhh.2010.122


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