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Vitamin D Status in Paediatric Patients With Cancer

Lookup NU author(s): Dr Akash Sinha, Dr Peter Avery, Professor Simon Bailey, Dr Timothy Cheetham

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Abstract

Background. Children with malignant disease are at increased risk of bone disorders and cardiovascular disease. Vitamin D status may influence this risk and so we assessed vitamin D levels in children with malignant disease undergoing active treatment or surveillance post-therapy. Procedure. This was an outpatient-based cross-sectional study of 61 children with a history of malignancy (median age 11.1 years; range 1.5-24.4 years) and 60 control subjects (median age 8.4 years; range 0.2-18.0 years) attending hospital for the management of non-malignant disorders. Serum vitamin D (25-OH-D), parathormone levels and bone biochemistry were determined. Vitamin D status and its relationship to age, sex, ethnicity, time of sampling and presence of malignant disease was determined. Results. Vitamin D status was suboptimal in 62% of cases (25-OH-D < 50 nmol/L [20 ng/ml]). Vitamin D deficiency (25-OH-D < 25 nmol/L [10 ng/ml]) was more common in children with malignant disease than controls (21.3% vs. 3.3%; P = 0.013). Month of sampling (P < 0.001), ethnicity (P < 0.001), older age (P = 0.011), and history of malignancy (P = 0.012) were associated with a poorer vitamin D status. Conclusions. Vitamin D levels [25-OH-D] are lower in survivors of childhood cancer in comparison to control children with the majority either insufficient or deficient. Assessment and adequate replacement of vitamin D status may be of particular value in this group of children. Pediatr Blood Cancer 2011;57:594-598. (C) 2011 Wiley-Liss, Inc.


Publication metadata

Author(s): Sinha A, Avery P, Turner S, Bailey S, Cheetham T

Publication type: Article

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2011

Volume: 57

Issue: 4

Pages: 594-598

Print publication date: 03/02/2011

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.22963

DOI: 10.1002/pbc.22963


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