Lookup NU author(s): Dr Jennifer Court,
Dr Margaret Piggott,
Emeritus Professor Elaine Perry,
Emeritus Professor Robert Perry
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[H-3]nicotine binding and choline acetyltransferase activity were measured in human frontal cortex, Brodman area 9, from brains obtained at autopsy from 47 cases aged between 24 weeks gestation to 100 years. The pattern of change of [H-3]nicotine binding during development and aging was not reflected in the changes of CHAT activity. [H-3]nicotine binding was reduced with age from birth to 100 years and this was not due to a change in affinity of the receptor for nicotine. CHAT activity initially rose from the perinatal period to a peak in the first decade and was then stable throughout the remaining years of life.
Author(s): Court JA, Piggott MA, Perry EK, Barlow RB, Perry RH
Publication type: Article
Publication status: Published
Journal: Neuroscience Research Communications
Print publication date: 01/05/1992
ISSN (print): 0893-6609
ISSN (electronic): 1520-6769
Publisher: John Wiley & Sons Ltd