Lookup NU author(s): Professor Alexander Thiele
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The brain continuously adapts its processing machinery to behavioural demands. To achieve this, it rapidly modulates the operating mode of cortical circuits, controlling the way that information is transformed and routed. This article will focus on two experimental approaches by which the control of cortical information processing has been investigated: the study of state-dependent cortical processing in rodents and attention in the primate visual system. Both processes involve a modulation of low-frequency activity fluctuations and spiking correlation, and are mediated by common receptor systems. We suggest that selective attention involves processes that are similar to state change, and that operate at a local columnar level to enhance the representation of otherwise non-salient features while suppressing internally generated activity patterns.
Author(s): Harris KD, Thiele A
Publication type: Review
Publication status: Published
Journal: Nature Reviews. Neuroscience
Pages: 509 - 523
Print publication date: 01/09/2011
ISSN (print): 1471-003X
ISSN (electronic): 1471-0048
Publisher: NATURE PUBLISHING GROUP
URL: http://dx.doi.org/ 10.1038/nrn3084
PubMed id: 21829219