Toggle Main Menu Toggle Search

ePrints

Gamma band pitch responses in human auditory cortex measured with magnetoencephalography.

Lookup NU author(s): Dr William Sedley, Dr Sukhbinder Kumar, Tobias Overath, Professor Tim Griffiths

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

We have previously used direct electrode recordings in two human subjects to identify neural correlates of the perception of pitch (Griffiths, Kumar, Sedley et al., Direct recordings of pitch responses from human auditory cortex, Curr. Biol. 22 (2010), pp. 1128-1132). The present study was carried out to assess virtual-electrode measures of pitch perception based on non-invasive magnetoencephalography (MEG). We recorded pitch responses in 13 healthy volunteers using a passive listening paradigm and the same pitch-evoking stimuli (regular interval noise; RIN) as in the previous study. Source activity was reconstructed using a beamformer approach, which was used to place virtual electrodes in auditory cortex. Time-frequency decomposition of these data revealed oscillatory responses to pitch in the gamma frequency band to occur, in Heschl's gyrus, from 60 Hz upwards. Direct comparison of these pitch responses to the previous depth electrode recordings shows a striking congruence in terms of spectrotemporal profile and anatomical distribution. These findings provide further support that auditory high gamma oscillations occur in association with RIN pitch stimuli, and validate the use of MEG to assess neural correlates of normal and abnormal pitch perception. (C) 2011 Elsevier Inc. All rights reserved.


Publication metadata

Author(s): Sedley W, Teki S, Kumar S, Overath T, Barnes GR, Griffiths TD

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2012

Volume: 59

Issue: 2

Pages: 1904-1911

Print publication date: 07/09/2011

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Academic Press

URL: http://dx.doi.org/10.1016/j.neuroimage.2011.08.098

DOI: 10.1016/j.neuroimage.2011.08.098

PubMed id: PMC3236996


Altmetrics

Altmetrics provided by Altmetric


Actions

    Link to this publication


Share