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Structural principles in cell-cycle control: beyond the CDKs

Lookup NU author(s): Professor Jane Endicott, Professor Martin Noble

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Abstract

Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for progression through the S phase of the cell cycle. Clues to the atomic mechanisms involved are offered by the structure of the two pocket regions of ph in complex with a short peptide from a viral oncoprotein. Structures of cyclins, ph and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control.


Publication metadata

Author(s): Noble MEM; Endicott JA

Publication type: Article

Publication status: Published

Journal: Structure

Year: 1998

Volume: 6

Issue: 5

Pages: 535-541

Print publication date: 01/05/1998

ISSN (print): 0969-2126

ISSN (electronic): 1878-4186

Publisher: Current Biology Ltd

URL: http://dx.doi.org/10.1016/S0969-2126(98)00055-0

DOI: 10.1016/S0969-2126(98)00055-0


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