Lookup NU author(s): Professor Jane Endicott,
Professor Martin Noble
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Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for progression through the S phase of the cell cycle. Clues to the atomic mechanisms involved are offered by the structure of the two pocket regions of ph in complex with a short peptide from a viral oncoprotein. Structures of cyclins, ph and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control.
Author(s): Noble MEM; Endicott JA
Publication type: Article
Publication status: Published
Print publication date: 01/05/1998
ISSN (print): 0969-2126
ISSN (electronic): 1878-4186
Publisher: Current Biology Ltd
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