Lookup NU author(s): Professor Martin Noble,
Professor Jane Endicott
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Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.
Author(s): Noble MEM; Endicott JA; Brown NR; Johnson LN
Publication type: Review
Publication status: Published
Journal: Trends in Biochemical Sciences
Print publication date: 01/12/1997
ISSN (print): 0968-0004
ISSN (electronic): 0167-7640
Publisher: ELSEVIER SCI LTD