ePrints

The cyclin box fold: protein recognition in cell-cycle and transcription control

Lookup NU author(s): Professor Martin NobleORCiD, Professor Jane Endicott

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.

Publication metadata

Author(s): Noble MEM; Endicott JA; Brown NR; Johnson LN

Publication type: Review

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 1997

Volume: 22

Issue: 12

Pages: 482-487

Print publication date: 01/12/1997

ISSN (print): 0968-0004

ISSN (electronic): 0167-7640

Publisher: ELSEVIER SCI LTD

URL: http://dx.doi.org/10.1016/S0968-0004(97)01144-4

DOI: 10.1016/S0968-0004(97)01144-4

Share