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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

Lookup NU author(s): Professor Martin Noble, Professor Jane Endicott

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Abstract

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 strauroporine complex explains the tight binding of this inhibitor and suggests features to be exploited in the design of specific inhibitors of CDKs.


Publication metadata

Author(s): Noble MEM; Endicott JA; Lawrie AM; Tunnah P; Brown NR; Johnson LN

Publication type: Letter

Publication status: Published

Journal: Nature Structural Biology

Year: 1997

Volume: 4

Issue: 10

Pages: 796-801

Print publication date: 01/10/1997

ISSN (print): 1072-8368

ISSN (electronic): 1545-9993

Publisher: NATURE PUBLISHING CO

URL: http://dx.doi.org/10.1038/nsb1097-796

DOI: 10.1038/nsb1097-796


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