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Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

Lookup NU author(s): Professor Jane Endicott

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Abstract

The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered as targets in the context of diseases caused by parasitic protists. Here, we present an overview of recent developments in this field, concentrating (i) on the benefits gained from the availability of genomic databases for a number of parasitic protozoa, (ii) on the emerging field of structure-aided design of inhibitors targeting protein kinases of parasitic protists, (iii) on the concept known as transmission-blockade, whereby kinases implicated in the development of the parasite in their arthropod vector might be targeted to interfere with disease transmission, and (iv) on the possibility of controlling parasitic diseases through the inhibition of host cell protein kinases that are required for the establishment of infection by the parasites.


Publication metadata

Author(s): Doerig C, Billker O, Pratt D, Endicott J

Publication type: Article

Publication status: Published

Journal: Biochimica et biophysica acta - Proteins and Proteomics

Year: 2005

Volume: 1754

Issue: 1-2

Pages: 132–150

ISSN (print): 1570-9639

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.bbapap.2005.08.027

DOI: 10.1016/j.bbapap.2005.08.027

PubMed id: 16271522

Notes: Inhibitors of Protein Kinases (4th International Conference, Inhibitors of Protein Kinases) and Associated Workshop: Modelling of Specific Molecular Recognition Processes (Warsaw, Poland, June 25-29, 2005)


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