ePrints

The diverse and complex roles of NF-kappa B subunits in cancer.

Lookup NU author(s): Professor Neil PerkinsORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

It is only recently that the full importance of nuclear factor-kappa B (NF-kappa B) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-kappa B activation, it is now becoming clear that the inhibitor of NF-kappa B kinases (IKKs), which regulate NF-kappa B activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-kappa B pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-kappa B subunits.

Publication metadata

Author(s): Perkins ND

Publication type: Review

Publication status: Published

Journal: Nature Reviews. Cancer

Year: 2012

Volume: 12

Issue: 2

Pages: 121-132

Print publication date: 19/01/2012

ISSN (print): 1474-175X

ISSN (electronic): 1474-1768

Publisher: NATURE PUBLISHING GROUP

URL: http://dx.doi.org/10.1038/nrc3204

DOI: 10.1038/nrc3204

Share