Lookup NU author(s): Dr Manon Grube,
Dr Katherina von Kriegstein,
Dr Sukhbinder Kumar,
Dr Thomas Kelly,
Professor Patrick Chinnery,
Professor Tim Griffiths
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A role for the cerebellum in cognition has been proposed based on studies suggesting a profile of cognitive deficits due to cerebellar stroke. Such studies are limited in the determination of the detailed organisation of cerebellar subregions that are critical for different aspects of cognition. In this study we examined the correlation between cognitive performance and cerebellar integrity in a specific degeneration of the cerebellar cortex: Spinocerebellar Ataxia type 6 (SCA6). The results demonstrate a critical relationship between verbal working memory and grey matter density in superior (bilateral lobules VI and crus I of lobule VII) and inferior (bilateral lobules VIIIa and VIIb, and right lobule IX) parts of the cerebellum. We demonstrate that distinct cerebellar regions subserve different components of the prevalent psychological model for verbal working memory based on a phonological loop. The work confirms the involvement of the cerebellum in verbal working memory and defines specific subsystems for this within the cerebellum. (C) 2011 Elsevier Ltd. All rights reserved.
Author(s): Cooper FE, Grube M, Von Kriegstein K, Kumar S, English P, Kelly TP, Chinnery PF, Griffiths TD
Publication type: Article
Publication status: Published
Print publication date: 25/11/2011
ISSN (print): 0028-3932
ISSN (electronic): 1873-3514
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