Toggle Main Menu Toggle Search

Open Access padlockePrints

Left ventricular torsion, energetics, and diastolic function in normal human aging

Lookup NU author(s): Dr Kieren Hollingsworth, Professor Andrew Blamire, Professor Bernard Keavney, Dr Guy MacGowan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Hollingsworth KG, Blamire AM, Keavney BD, MacGowan GA. Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol 302: H885-H892, 2012. First published December 6, 2011; doi: 10.1152/ajpheart. 00985.2011.-This study determined, for the first time, whether the effects of normal aging on systolic and diastolic left ventricular function in subjects without cardiovascular disease are related to underlying energetic defects. Cardiac magnetic resonance imaging with tissue tagging and P-31 spectroscopy was used to determine global structure, function, myocardial strains, and the phosphocreatine-to-ATP ratio (PCr/ATP) in 49 healthy subjects aged 20-69 yr. The three major abnormalities that developed with increasing age were the early filling percentage (EFP, the left ventricular volume increase from end systole to mid-diastole divided by stroke volume x 100), which decreased with age, indicating impaired early diastolic filling (r = -0.72, P < 0.0001), the torsion-to-shortening ratio (TSR, measure of subepicardial torsion exerting mechanical advantage over subendocardial shortening), which increased with age indicating relative subendocardial dysfunction (r = 0.44, P < 0.02), and the PCr/ATP (decreased with increasing age, r = -0.52, P < 0.003). EFP and TSR were strongly correlated (r = -0.63, P < 0.0001), although they were not related to PCr/ATP [EFP vs. PCr/ATP: r = 0.34, not significant (NS) and TSR vs. PCr/ATP: r = -0.3, P = NS]. In normal aging, changes in EFP and TSR likely share the same pathophysiology, although it is unlikely that energetics have a major role in the functional effects of aging.


Publication metadata

Author(s): Hollingsworth KG, Blamire AM, Keavney BD, MacGowan GA

Publication type: Article

Publication status: Published

Journal: American Journal of Physiology: Heart and Circulatory Physiology

Year: 2012

Volume: 302

Issue: 4

Pages: H885-H892

Print publication date: 01/12/2011

ISSN (print): 0363-6135

ISSN (electronic):

Publisher: American Physiological Society

URL: http://dx.doi.org/10.1152/ajpheart.00985.2011

DOI: 10.1152/ajpheart.00985.2011


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share