Lookup NU author(s): Dr Olivier Joly
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Diffusion-weighted MRI of non-human primates revealed that USPIO Bulk Magnetic Susceptibility (BMS) T2’ effects of Ultrasmall Superparamagnetic Particles with Iron Oxide (USPIO) in the brain cannot be explained by a single compartment model, as diffusion and T2’ effects appear coupled: Apparent Diffusion Coefficient (ADC) values depend on USPIO concentration and relaxivity effects of USPIO decrease with the b value. On the other hand, USPIO and diffusion effects could be well uncoupled using a model consisting in a fast and a slow diffusion pool with different relaxivities. Diffusion-weighting acts as a filter which emphasizes the contribution of the slow pool when increasing b values (apparent decrease in ADC and R2’). Those results have implications for human studies using BMS contrast agents, as well as BOLD and diffusion fMRI.
Author(s): Le Bihan D, Joly O, Aso T, Uhrig L, Poupon C, Tani N, Iwamuro H, Urayama S-I, Jarraya B
Publication type: Article
Publication status: Published
Print publication date: 11/05/2012
ISSN (print): 1053-8119
ISSN (electronic): 1095-9572
Publisher: Academic Press
Altmetrics provided by Altmetric