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Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

Lookup NU author(s): Dr Matthew Barter, Dr Catherine Bui, Professor David Young

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Abstract

Osteoarthritis (OA) is a complex multifactorial disease with a strong genetic component. Several studies have suggested or identified epigenetic events that may play a role in OA progression and the gene expression changes observed in diseased cartilage. The aim of this review is to inform about current research in epigenetics and epigenetics in OA. Epigenetic mechanisms include DNA methylation, histone modifications, and microRNAs. Collectively, these enable the cell to respond quickly to environmental changes and can be inherited during cell division. However, aberrant epigenetic modifications are associated with a number of pathological conditions, including OA. Advancements in epigenetic research suggests that global analysis of such modifications in OA are now possible, however, with the exception of microRNAs, it will be a significant challenge to demonstrate how such events impact on the disease. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Barter MJ, Bui C, Young DA

Publication type: Review

Publication status: Published

Journal: Osteoarthritis and Cartilage

Year: 2012

Volume: 20

Issue: 5

Pages: 339-349

Print publication date: 10/01/2012

ISSN (print): 1063-4584

ISSN (electronic): 1522-9653

Publisher: ELSEVIER SCI LTD

URL: http://dx.doi.org/10.1016/j.joca.2011.12.012

DOI: 10.1016/j.joca.2011.12.012


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