Lookup NU author(s): Dr Francesco Bruni,
Dr Pasqua Gramegna,
Professor Robert Lightowlers,
Professor Zofia Chrzanowska-Lightowlers
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The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis- and transacting elements will play a role in the outcome. The present review concentrates on just one aspect of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion.
Author(s): Bruni F, Gramegna P, Lightowlers RN, Chrzanowska-Lightowlers ZMA
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 01/08/2012
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press Ltd.
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