Lookup NU author(s): Dr Paula Salgado
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Candida albicans is a common human fungal commensal that can also cause a range of infections from skin/mucosal `thrush' to severe systemic candidiasis. Adherence to host cells is one of the key determinants of Candida pathogenesis. The Als family of surface proteins has been implicated in adhesion of C. albicans, yet limited information has been published on the structure and mechanism of these fungal adhesins. The N-terminal region of these proteins has been shown to possess adhesive properties, making it a possible target for new therapeutic strategies. Recombinant NT-Als9-2 from C. albicans (residues 18-329) was overexpressed in Escherichia coli, purified and crystallized. Diffraction data were collected to 2.0 Å resolution. The crystals belonged to space group P212121, with unit-cell parameters a = 34.73, b = 68.71, c = 120.03 Å, [alpha] = [beta] = [gamma] = 90° and one molecule in the asymmetric unit. Platinum-derivatized crystals belonged to the same space group, with similar unit-cell parameters, although they were not completely isomorphous.
Author(s): Salgado PS, Yan R, Rowan F, Cota E
Publication type: Article
Publication status: Published
Journal: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications
Print publication date: 01/04/2011
ISSN (electronic): 1744-3091
Publisher: Wiley-Blackwell Publishing, Inc.
PubMed id: 21505243
Altmetrics provided by Altmetric