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Evaluation of tetraethylammonium bicarbonate as a phase-transfer agent in the formation of [18F]fluoroarenes

Lookup NU author(s): Christopher Reed, Dr Guillaume Launay, Dr Michael Carroll

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Abstract

Tetraethylammonium bicarbonate, Et4N center dot HCO3, was found to be an efficient phase-transfer agent, in a microreactor, for the production of [F-18]fluoroarenes from a range of precursors (diaryliodonium salt, nitroarene and [F-19]fluoroarene). This study has established Et4N center dot HCO3 as a practical alternative to the conventional phase-transfer system - Kryptofix (R) 222/K2CO3 - as the radiolabelled products were generated in comparable radiochemical yields. The use of Et4N center dot HCO3 also dramatically increased productivity by eliminating the frequent blockages of the microreactor experienced with the traditional system. (C) 2012 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Reed CD, Launay GG, Carroll MA

Publication type: Article

Publication status: Published

Journal: Journal of Fluorine Chemistry

Year: 2012

Volume: 143

Pages: 231-237

Print publication date: 01/11/2012

ISSN (print): 0022-1139

ISSN (electronic): 1873-3328

Publisher: Elsevier S.A.

URL: http://dx.doi.org/10.1016/j.jfluchem.2012.07.015

DOI: 10.1016/j.jfluchem.2012.07.015


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