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How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

Lookup NU author(s): Professor Jarka Glassey

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Abstract

This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in (MC)-C-3 are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting (MC)-C-3 research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.


Publication metadata

Author(s): Carrondo MJT, Alves PM, Carinhas N, Glassey J, Hesse F, Merten OW, Micheletti M, Noll T, Oliveira R, Reichl U, Staby A, Teixeira AP, Weichert H, Mandenius CF

Publication type: Article

Publication status: Published

Journal: Biotechnology Journal

Year: 2012

Volume: 7

Issue: 12

Pages: 1522-1529

Print publication date: 05/09/2012

ISSN (print): 1860-6768

ISSN (electronic): 1860-7314

Publisher: Wiley - V C H Verlag GmbH & Co. KGaA

URL: http://dx.doi.org/10.1002/biot.201200226

DOI: 10.1002/biot.201200226


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