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Regulation of gene expression by the RNA-binding protein Sam68 in cancer

Lookup NU author(s): Dr Prabhakar Rajan, Dr Luke GaughanORCiD, Caroline Dalgliesh, Dr Amira El-Sherif, Professor Craig Robson, Professor Hing Leung, Professor David Elliott

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Abstract

Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the present review, we summarize the functions of Sam68 as a transcriptional and post-transcriptional regulator of gene expression, with particular relevance to cancer.

Publication metadata

Author(s): Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2008

Volume: 36

Issue: 3

Pages: 505-507

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0360505

DOI: 10.1042/BST0360505

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