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Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes

Lookup NU author(s): Dr Evelyn Jaros, Emeritus Professor Robert Perry

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Abstract

Y. S. Davidson, A. C. Robinson, Q. Hu, M. Mishra, A. Baborie, E. Jaros, R. H. Perry, N. J. Cairns, A. Richardson, A. Gerhard, D. Neary, J. S. Snowden, E. H. Bigio and D. M. A. Mann (2013) Neuropathology and Applied Neurobiology39, 157 165 Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes Aims: We aimed to investigate the role of the nuclear carrier and binding proteins, transportin 1 (TRN1) and transportin 2 (TRN2), TATA-binding protein-associated factor 15 (TAF15) and Ewing's sarcoma protein (EWS) in inclusion body formation in cases of frontotemporal lobar degeneration (FTLD) associated with fused in sarcoma protein (FTLD-FUS). Methods: Eight cases of FTLD-FUS (five cases of atypical FTLD-U, two of neuronal intermediate filament inclusion body disease and one of basophilic inclusion body disease) were immunostained for FUS, TRN1, TRN2, TAF15 and EWS. Ten cases of FTLD associated with TDP-43 inclusions served as reference cases. Results: The inclusion bodies in FTLD-FUS contained TRN1 and TAF15 and, to a lesser extent, EWS, but not TRN2. The patterns of immunostaining for TRN1 and TAF15 were very similar to that of FUS. None of these proteins was associated with tau or TDP-43 aggregations in FTLD. Conclusions: Data suggest that FUS, TRN1 and TAF15 may participate in a functional pathway in an interdependent way, and imply that the function of TDP-43 may not necessarily be in parallel with, or complementary to, that of FUS, despite each protein sharing many similar structural elements.


Publication metadata

Author(s): Davidson YS, Robinson AC, Hu Q, Mishra M, Baborie A, Jaros E, Perry RH, Cairns NJ, Richardson A, Gerhard A, Neary D, Snowden JS, Bigio EH, Mann DMA

Publication type: Article

Publication status: Published

Journal: Neuropathology and Applied Neurobiology

Year: 2013

Volume: 39

Issue: 2

Pages: 157-165

Print publication date: 25/01/2013

ISSN (print): 0305-1846

ISSN (electronic): 1365-2990

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2990.2012.01274.x

DOI: 10.1111/j.1365-2990.2012.01274.x


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Funding

Funder referenceFunder name
Alzheimers Research UK
Alzheimer's Society under the Brains for Dementia Research (BDR) initiative
Friedman Award
Wellcome Trust
Ministry of Education of People's Republic of China
MRC
UK NIHR Biomedical Research Centre for Ageing and Age-related disease
AG13854Northwestern ADC
B08006'Project on Absorption of Intellects by Institutions of Higher Education for Academic Disciplinary Innovations' (the ;111 Project')
G0400074UK Medical Research Council
G110054UK Medical Research Council
IRT0810Program for Changjiang Scholars and Innovative Research Team in University
P01 AG03991National Institute on Aging of the National Institutes of Health
P50 AG05681National Institute on Aging of the National Institutes of Health

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