Lookup NU author(s): Dr Alison Yarnall,
Professor Lynn Rochester,
Dr Mark Baker,
Dr Tien Khoo,
Dr Gordon Duncan,
Dr Brook Galna,
Professor David Burn
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BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. METHODS: Twenty-two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electricalstimuli delivered to the contralateral median nerve at varying interstimulus intervals. RESULTS: There was no significant difference between cognitively normal PD and controls for short latency afferent inhibition (62.8±30.3% vs. 55.7±21.7%; P=0.447). The PD-mild cognitive impairment group had significantly less inhibition (88.4±25.8%) than both cognitively normal PD (P=0.021) andcontrols (P=0.01). CONCLUSIONS: Cholinergic dysfunction occurs early in those with PD -mild cognitive impairment. Short latency afferent inhibition may be a useful biomarker of increased risk of dementia in PD patients.
Author(s): Yarnall AJ, Rochester L, Baker MR, David R, Khoo TK, Duncan GW, Galna B, Burn DJ
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Print publication date: 01/08/2013
Online publication date: 28/02/2013
Acceptance date: 09/12/2012
Date deposited: 18/03/2013
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley & Sons, Inc.
PubMed id: 23450646
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