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Structural variability of the ubiquitin specific protease DUSP-UBL double domains

Lookup NU author(s): Dr Martyna Pastok

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Abstract

USP4, 11 and 15 are three closely related paralogues of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. The DUSP domain and the UBL domain in these proteins are juxtaposed which may provide a functional unit conferring specificity. We determined the structures of the USP15 DUSP-UBL double domain unit in monomeric and dimeric states. We then conducted comparative analysis of the structural and physical properties of all three DUSP-UBL units. We identified structural features that dictate different dispositions between constituent domains, which in turn may influence respective binding properties


Publication metadata

Author(s): Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbé S, Barsukov IL

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2011

Volume: 585

Issue: 21

Pages: 3385–3390

Print publication date: 10/10/2011

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.febslet.2011.09.040

DOI: 10.1016/j.febslet.2011.09.040


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