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A review of tasquinimod in the treatment of advanced prostate cancer

Lookup NU author(s): Dr Stuart Williamson, Dr Alice Hartley, Professor Rakesh Heer

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Abstract

Castration resistant prostate cancer remains a major clinical burden and novel-therapeutic options are urgently required to improve survival. Tasquinimod is an orally-administered quinoline-3-carboxamide with potent antiangiogenic and antitumorigenic action that has shown promise in the treatment of advanced prostate cancers. This review explores both preclinical and clinical findings to date. In summary, tasquinimod has been shown to demonstrate a potent in vitro and in vivo anticancer action and completed early phase clinical trials have demonstrated good drug tolerance and prolonged progression-free survival. Although Phase III clinical trials are on-going, the findings to date highlight the promise of this drug in the treatment of advanced prostate cancer.


Publication metadata

Author(s): Williamson SC, Hartley AE, Heer R

Publication type: Review

Publication status: Published

Journal: Drug Design, Development and Therapy

Year: 2013

Volume: 7

Pages: 167-174

Print publication date: 21/03/2013

ISSN (print): 1177-8881

ISSN (electronic):

Publisher: DOVE MEDICAL PRESS LTD

URL: https://doi.org/10.2147/DDDT.S31500

DOI: 10.2147/DDDT.S31500


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