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Health-related utility values of patients with primary Sjögren's syndrome and its predictors

Lookup NU author(s): Dr Dennis Lendrem, Sheryl Mitchell, Dr Peter McMeekin, Dr Bridget Griffiths, Professor Fai Ng

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Abstract

Objectives: EuroQoL-5 dimension (EQ-5D) is a standardised, preference-based tool for measurement of health-related quality of life and EQ-5D utility values can be converted to Quality Adjusted Life Years (QALY) to aid cost-utility analysis. This study aimed to evaluate the EQ-5D utility values of 639 primary Sjögren’s syndrome (PSS) patients from the UK PSS registry.Methods: Prospective data collected using a standardised pro forma were compared to UK normative data. Relationships between utility values and the clinical and laboratory features of PSS were explored.Results: The proportion (%) of PSS patients reporting any problem in mobility, self-care, usual activities, pain/discomfort & anxiety/depression were 42.2, 16.7, 56.6, 80.6 & 49.4 respectively, compared to 5.4, 1.6, 7.9, 30.2 & 15.7 for the UK general population. The median EQ-5D utility values was 0.691 (Interquartile range: 0.587-0.796, range: -0.239 to 1.000), with a bi-modal distribution. Bivariate correlation analysis revealed significant correlation between EQ-5D utility values and many clinical features of PSS but most strongly with pain, depression and fatigue (R values >0.5). After adjusting for age and sex differences, multiple regression analysis identified pain and depression asthe two most important predictors of EQ-5D utility values accounting for 48% of the variability. Anxiety, fatigue, and body mass index were other statistically significant predictors but accounting for <5% in variability.Discussion: This is the first report on the EQ-5D utility values of PSS patients. PSS patients have significantly impaired utility values compared to the UK general population. EQ-5D utility values are significantly related to pain and depression scores in PSS.


Publication metadata

Author(s): Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease C, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots S, Gendi N, Akil M, Griffiths B, Ng W-F

Publication type: Article

Publication status: Published

Journal: Annals of Rheumatic Diseases

Year: 2014

Volume: 73

Issue: 7

Pages: 1362-1368

Print publication date: 01/05/2013

ISSN (print): 0003-4967

ISSN (electronic): 1468-2060

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/annrheumdis-2012-202863

DOI: 10.1136/annrheumdis-2012-202863


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