Toggle Main Menu Toggle Search

Open Access padlockePrints

Amyloid PET Imaging in Lewy Body Disorders

Lookup NU author(s): Dr Paul Donaghy, Professor Alan Thomas, Professor John O'Brien

Downloads


Licence

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

Lewy body (LB) disorders, including Parkinson’s disease (PD), Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are the second most common type of neurodegenerative dementia. Although the pathological hallmarks of LB disorders are Lewy bodies and Lewy neurites, cortical amyloid-beta (Aβ) deposition is also often seen. The relationship between Aβ pathology and dementia in LB disorders is unclear. Recently, PET Aβ ligands have been developed that enable in vivo imaging of Aβ. In this paper we review amyloid imaging studies in LB disorders. LB disorders are associated with lower mean cortical Aβ ligand binding compared with Alzheimer’s Disease. In DLB and PDD many subjects have normal levels of cortical Aβ, though a subset show increased Aβ ligand binding. Those with DLB show greater ligand binding than PDD; binding does not appear to be increased in PD without dementia. Cortical Aβ deposition may be a factor in the development of cognitive impairment in some cases of dementia in LB disorders. Amyloid imaging is of limited use in the diagnosis of LB disorders but Aβ deposition may predict the future development of dementia in PD. Reports of correlation between Aβ deposition and symptom profile, severity and progression have been inconsistent. Some results suggest a synergistic interaction between Aβ and α-synuclein. Interpretation of the current evidence is hampered by differing methodologies across studies, and small sample sizes. Large, prospective longitudinal studies are needed to clarify the association of Aβ with symptom development, progression, severity and treatment response in LB disorders.


Publication metadata

Author(s): Donaghy P, Thomas AJ, O'Brien JT

Publication type: Article

Publication status: Published

Journal: American Journal of Geriatric Psychiatry

Year: 2015

Volume: 23

Issue: 1

Pages: 23-37

Print publication date: 01/01/2015

Online publication date: 03/07/2013

Acceptance date: 01/03/2013

Date deposited: 10/06/2013

ISSN (print): 1064-7481

ISSN (electronic): 1545-7214

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.jagp.2013.03.001

DOI: 10.1016/j.jagp.2013.03.001

PubMed id: 23831180


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share