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Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection

Lookup NU author(s): Dr Timothy Bates, Dr Max RobinsonORCiD

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Abstract

Small cell carcinoma/neuroendocrine carcinoma (SCNEC) of the oropharynx is uncommon. Recently, an association has been reported between oropharyngeal SCNEC and high-risk human papillomavirus (HPV) infection. While HPV infection confers a better prognosis for oropharyngeal squamous cell carcinoma, HPV infection does not appear to influence the biological behaviour of SCNECs, which are generally associated with poor clinical outcomes. We document two cases of SCNEC arising in the oropharynx with evidence of high-risk HPV infection. The cases highlight the expanding range of malignant oropharyngeal neoplasms that harbour oncogenic HPV infection and support the concept that, irrespective of HPV infection, neuroendocrine differentiation portends a poor prognosis.

Publication metadata

Author(s): Bates T, McQueen A, Iqbal MS, Kelly C, Robinson M

Publication type: Article

Publication status: Published

Journal: Head and Neck Pathology

Year: 2014

Volume: 8

Issue: 1

Pages: 127-131

Print publication date: 01/03/2014

Online publication date: 10/07/2013

Acceptance date: 27/06/2013

ISSN (print): 1936-055X

ISSN (electronic): 1936-0568

Publisher: Springer US

URL: http://dx.doi.org/10.1007%2Fs12105-013-0471-y

DOI: 10.1007%2Fs12105-013-0471-y

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