Lookup NU author(s): Professor Nikolay Zenkin
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The highly streamlined mitochondrial genome encodes almost exclusively a handful of transmembrane components of the respiratory chain complex. In order to ensure the correct assembly of the respiratory chain, the products of these genes must be produced in the correct stoichiometry and inserted into the membrane, posing a unique challenge to the mitochondrial translational system. In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components – mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the fast rate of evolution in these organelles has not only created a system that is divergent from that of its bacterial ancestors, but has led to a huge diversity in lineage specific mechanistic features of mitochondrial translation initiation among eukaryotes.
Author(s): Kuzmenko A, Atkinson GC, Levitskii S, Zenkin N, Tenson T, Hauryliuk V, Kamenski P
Publication type: Article
Publication status: Published
Print publication date: 01/05/2014
Online publication date: 14/08/2013
Acceptance date: 29/07/2013
Date deposited: 24/03/2014
ISSN (print): 0300-9084
ISSN (electronic): 1638-6183
Publisher: Elsevier Masson
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