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Liver and muscle glycogen repletion using C-13 magnetic resonance spectroscopy following ingestion of maltodextrin, galactose, protein and amino acids

Lookup NU author(s): Dr Peter Thelwall, Dr Fiona Smith, Dr Djordje Jakovljevic, Professor Michael Trenell

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Abstract

The present study evaluated whether the inclusion of protein (PRO) and amino acids (AA) within a maltodextrin (MD) and galactose (GAL) recovery drink enhanced post-exercise liver and muscle glycogen repletion. A total of seven trained male cyclists completed two trials, separated by 7 d. Each trial involved 2 h of standardised intermittent cycling, followed by 4 h recovery. During recovery, one of two iso-energetic formulations, MD-GAL (0.9 g MD/kg body mass (BM) per h and 0.3 g GAL/kg BM per h) or MD-GAL-PRO + AA (0.5 g MD/kg BM per h, 0.3 g GAL/kg BM per h, 0.4 g whey PRO hydrolysate plus L-leucine and L-phenylalanine/kg BM per h) was ingested at every 30 min. Liver and muscle glycogen were measured after depletion exercise and at the end of recovery using H-1-C-13-magnetic resonance spectroscopy. Despite higher postprandial insulin concentations for MD-GAL-PRO + AA compared with MD-GAL (61.3 (SE 6.2) v. 29.6 (SE 3.0) mU/l, (425.8 (SE 43.1) v. 205.6 (SE 20.8) pmol/l) P=0.03), there were no significant differences in post-recovery liver (195.3 (SE 2.6) v. 213.8 (SE 18.0) mmol/l) or muscle glycogen concentrations (49.7 (SE 4.0) v. 51.1 (SE 7.9) mmol/l). The rate of muscle glycogen repletion was significantly higher for MD-GAL compared with MD-GAL-PRO + AA (5.8 (SE 0.7) v. 3.7 (SE 0.6) mmol/l per h, P=0.04), while there were no significant differences in the rate of liver glycogen repletion (15.0 (SE 2.5) v. 13.0 (SE 2.7) mmol/l per h). PRO and AA within a MD-GAL recovery drink, compared with an isoenergetic mix of MD-GAL, did not enhance but matched liver and muscle glycogen recovery. This suggests that the increased postprandial insulinaemia only compensated for the lower MD content in the MD-GAL-PRO + AA treatment.


Publication metadata

Author(s): Detko E, O'Hara JP, Thelwall PE, Smith FE, Jakovljevic DG, King RFGJ, Trenell MI

Publication type: Article

Publication status: Published

Journal: British Journal of Nutrition

Year: 2013

Volume: 110

Issue: 5

Pages: 848-855

Print publication date: 06/02/2013

ISSN (print): 0007-1145

ISSN (electronic): 1475-2662

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S0007114512005818

DOI: 10.1017/S0007114512005818


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