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Capsaicin-induced neurogenic inflammation in pig skin: A behavioural study

Lookup NU author(s): Dr Pierpaolo Di Giminiani

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Abstract

Topical capsaicin is a well-established model of experimental hyperalgesia. Its application to the study of animals has been limited to few species. The effect of topical capsaicin on hyperalgesia in porcine skin was evaluated as part of a study of inflammatory pain in the pig. Two experiments were carried out on pigs of 27 ± 5 kg (n = 8) and 57 ± 3 kg (n = 16). Thermal and mechanical noxious stimuli were provided (CO₂ laser and Pressure Application Measurement device) to assess avoidance behaviours. Capsaicin induced significant thermal hyperalgesia in the smaller pigs (P < 0.05), while no mechanical hyperalgesia was observed in either animal group. The present model of topical capsaicin application may be useful to investigate the mechanisms of primary hyperalgesia in this species, although some experimental conditions, such as the administration route and cutaneous morphology, need to be evaluated.

Publication metadata

Author(s): Di Giminiani P, Petersen LJ, Herskin MS

Publication type: Article

Publication status: Published

Journal: Research in Veterinary Science

Year: 2014

Volume: 96

Issue: 3

Pages: 447-453

Print publication date: 01/06/2014

Online publication date: 02/04/2014

Acceptance date: 30/03/2014

ISSN (print): 0034-5288

ISSN (electronic): 1532-2661

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.rvsc.2014.03.023

DOI: 10.1016/j.rvsc.2014.03.023

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