Lookup NU author(s): Dr Soren Nielsen,
Professor Nikolay Zenkin
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Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before divergence of bacteria and archaea/eukaryotes.
Author(s): Nielsen S, Zenkin N
Publication type: Article
Publication status: Published
Print publication date: 08/11/2013
ISSN (print): 2154-1264
ISSN (electronic): 2154-1272
Publisher: Landes Bioscience
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