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Transcript assisted phosphodiester bond hydrolysis by eukaryotic RNA polymerase II

Lookup NU author(s): Dr Soren Nielsen, Professor Nikolay Zenkin

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Abstract

Hydrolysis of the phosphodiester bonds of the transcript by bacterial RNA polymerase is assisted by 3′NMP of the RNA. Here we provide evidence that this mechanism is also involved in RNA cleavage by eukaryotic RNA polymerase II, suggesting that transcript assisted hydrolysis has emerged before divergence of bacteria and archaea/eukaryotes.


Publication metadata

Author(s): Nielsen S, Zenkin N

Publication type: Article

Publication status: Published

Journal: Transcription

Year: 2013

Volume: 4

Issue: 5

Pages: 209-212

Print publication date: 08/11/2013

ISSN (print): 2154-1264

ISSN (electronic): 2154-1272

Publisher: Landes Bioscience

URL: http://dx.doi.org/10.4161/trns.27062

DOI: 10.4161/trns.27062


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