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Adolescent Brain Maturation and Cortical Folding: Evidence for Reductions in Gyrification

Lookup NU author(s): Sharmili Sritharan, Dr Cheol Han, Professor Marcus Kaiser

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development.


Publication metadata

Author(s): Klein D, Rotarska-Jagiela A, Genc E, Sritharan S, Mohr H, Roux F, Han CE, Kaiser M, Singer W, Uhlhaas PJ

Publication type: Article

Publication status: Published

Journal: PLoS One

Year: 2014

Volume: 9

Issue: 1

Online publication date: 15/01/2014

Acceptance date: 28/11/2013

ISSN (electronic): 1932-6203

Publisher: Public Library of Science

URL: http://dx.doi.org/10.1371/journal.pone.0084914

DOI: 10.1371/journal.pone.0084914

Notes: ARTN e84914


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