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Lookup NU author(s): Julian Leathart, Professor Ann DalyORCiD, Professor Chris Day, Professor Quentin AnsteeORCiD
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Background & aim: Non-alcohol-related fatty liver disease (NAFLD) encompasses a wide spectrum ranging from steatosis alone to steatohepatitis and fibrosis. Presence of steatohepatitis and fibrosis are key hallmarks of disease progression. Previous studies have demonstrated an association between hepatocyte p21 expression and fibrosis stage in NAFLD. The aim of this study is to investigate the association between the variants of CDKN1A, which encodes p21, and disease progression in NAFLD. Methods: The relation of CDKN1A polymorphism with steatohepatitis and fibrosis was studied in two cohorts of biopsy-proven NAFLD patients from UK (n=323) and Finland (n=123). Genotyping was performed using DNA isolated from lymphocytes collected at the time of liver biopsy. The findings of the UK cohort were tested in the Finnish cohort. Results: Both the UK and Finnish cohorts were significantly different from each other in basic demographics. In the UK cohort, rs762623 of the six SNPs across CDKN1A tested was significantly associated with disease progression in NAFLD. This association was confirmed in the Finnish cohort. Despite the influence on fibrosis development, SNPs across CDKN1A did not affect the progression of liver fibrosis. Conclusion: CDKN1A variant rs762623 is associated with the development but not the propagation of progressive liver disease in NAFLD.
Author(s): Aravinthan A, Mells G, Allison M, Leathart J, Kotronen A, Yki-Jarvinen H, Daly AK, Day CP, Anstee QM, Alexander G
Publication type: Article
Publication status: Published
Journal: Cell Cycle
Year: 2014
Volume: 13
Issue: 9
Pages: 1489-1494
Print publication date: 11/03/2014
Date deposited: 01/03/2015
ISSN (print): 1538-4101
ISSN (electronic): 1551-4005
Publisher: Landes Bioscience
URL: http://dx.doi.org/10.4161/cc.28471
DOI: 10.4161/cc.28471
PubMed id: 24626178
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