Lookup NU author(s): Dr Nicholas Jakubovics,
Professor Grant Burgess
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The death and lysis of microbial cells leads to the release of cytoplasmic contents, many of which are rapidly degraded by enzymes. However, some macromolecules survive intact and find new functions in the extracellular environment. There is now strong evidence that DNA released from cells during lysis, or sometimes by active secretion, becomes a key component of the macromolecular scaffold in many different biofilms. Enzymatic degradation of extracellular DNA can weaken the biofilm structure and release microbial cells from the surface. Many bacteria produce extracellular deoxyribonuclease (DNase) enzymes that are apparently tightly regulated to avoid excessive degradation of the biofilm matrix. Interfering with these control mechanisms, or adding exogenous DNases, could prove a potent strategy for controlling biofilm growth.
Author(s): Jakubovics NS, Shields RC, Rajarajan N, Burgess JG
Publication type: Review
Publication status: Published
Journal: Letters in Applied Microbiology
Print publication date: 01/08/2013
ISSN (print): 0266-8254
ISSN (electronic): 1472-765X
PubMed id: 23848166