Lookup NU author(s): Dr Sean Colloby,
Professor John O'Brien,
Professor John-Paul Taylor
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Evidence suggests that the cerebellum contributes to cognition as well as motor function. We investigated cerebellar grey matter (GM) and white matter (WM) changes from magnetic resonance images in dementia with Lewy bodies (DLB), Alzheimer׳s disease (AD) and healthy older subjects using voxel-based morphometry (VBM). Subjects (39 controls, 41 DLB, and 48 AD) underwent magnetic resonance imaging as well as clinical and cognitive assessments. VBM used SPM8 with a cerebellar brain mask to define the subspace for voxel analysis. Statistical analyses were conducted using the general linear model. Relative to findings in controls, VBM analysis revealed cerebellar GM loss in lobule VI bilaterally in AD and in left Crus I and right Crus II regions in DLB. WM deficits were confined to AD in the bilateral middle cerebellar peduncles. DLB demonstrates a different pattern of cerebellar GM loss which, although not significantly different from that in AD, could be an important feature in understanding the neurobiology of DLB and warrants further investigation.
Author(s): Colloby SJ, O'Brien JT, Taylor J-P
Publication type: Article
Publication status: Published
Journal: Psychiatric Research: Neuroimaging
Print publication date: 30/09/2014
Online publication date: 30/06/2014
Acceptance date: 19/06/2014
Date deposited: 29/08/2014
ISSN (print): 0925-4927
ISSN (electronic): 1872-7506
Altmetrics provided by Altmetric