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Emerging immunotherapies for rheumatoid arthritis

Lookup NU author(s): Dr Gary Reynolds, Dr Faye Cooles, Professor John Isaacs, Dr Catharien Hilkens

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Abstract

Novel treatments in development for rheumatoid arthritis target 3 broad areas: cytokines, cells, and signaling pathways. Therapies from each domain share common advantages (for example previously demonstrated efficacy, potential long-term immunomodulation, and oral administration respectively) that have stimulated research in each area but also common obstacles to their development. In this review recent progress in each area will be discussed alongside the factors that have impeded their path to clinical use.


Publication metadata

Author(s): Reynolds G, Cooles FAH, Isaacs JD, Hilkens CMU

Publication type: Review

Publication status: Published

Journal: Human Vaccines & Immunotherapeutics

Year: 2014

Volume: 10

Issue: 4

Pages: 822-837

Print publication date: 17/02/2014

ISSN (print): 2164-5515

ISSN (electronic): 2164-554X

Publisher: LANDES BIOSCIENCE

URL: http://dx.doi.org/10.4161/hv.27910

DOI: 10.4161/hv.27910


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