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Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study

Lookup NU author(s): Professor Alison Yarnall, Dr Gordon Duncan, Dr Shirley ColemanORCiD, Dr Michael FirbankORCiD, Professor Gavin Hudson, Professor Patrick Chinnery, Professor John O'Brien, Professor David BrooksORCiD, Ruth Barker, Professor David Burn

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Abstract

Objective:To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.Methods:Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.Results:The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the cognitively normal PD group. A significant correlation was found between visual Pattern Recognition Memory and cerebrospinal -amyloid 1-42 levels ( standardized coefficient = 0.350; p = 0.008) after controlling for age and education in a linear regression model, with lower -amyloid 1-42 and 1-40 levels observed in those with PD-MCI. Voxel-based morphometry did not reveal any areas of significant gray matter loss in participants with PD-MCI compared with controls, and no specific genotype was associated with PD-MCI at the 1.5-SD threshold.Conclusions:In a large cohort of newly diagnosed PD participants, PD-MCI is common and significantly correlates with lower cerebrospinal -amyloid 1-42 and 1-40 levels. Future longitudinal studies should enable us to determine those measures predictive of cognitive decline.


Publication metadata

Author(s): Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ, ICICLE-PD Study Group

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2014

Volume: 82

Issue: 4

Pages: 308-316

Print publication date: 20/12/2013

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1212/WNL.0000000000000066

DOI: 10.1212/WNL.0000000000000066


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Funding

Funder referenceFunder name
Michael J. Fox Foundation (MJFF)
NIHR Biomedical Research Centre
Parkinson's UK
Lockhart Parkinson's Disease Research Fund
NIHR Newcastle Biomedical Research Unit at Newcastle upon Tyne Hospitals NHS Foundation Trust/Newcastle University
NIHR, through the Dementias and Neurodegenerative Diseases Research Network
101876/Z/13/ZWellcome Trust

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