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Serotonin paracrine signaling in tissue fibrosis

Lookup NU author(s): Professor Derek Mann, Professor Fiona Oakley

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Abstract

The molecule serotonin (5-hydroxytryptamine or 5-HT) is involved in numerous biological processes both inside and outside of the central nervous system. 5-HT signals through 5-HT receptors and it is the diversity of these receptors and their subtypes that give rise to the varied physiological responses. It is clear that platelet derived serotonin is critical for normal wound healing in multiple organs including, liver, lung heart and skin. 5-HT stimulates both vasoconstriction and vasodilation, influences inflammatory responses and promotes formation of a temporary scar which acts as a scaffold for normal tissue to be restored. However, in situations of chronic injury or damage 5-HT signaling can have deleterious effects and promote aberrant wound healing resulting in tissue fibrosis and impaired organ regeneration. This review highlights the diverse actions of serotonin signaling in the pathogenesis of fibrotic disease and explores how modulating the activity of specific 5-HT receptors, in particular the 5-HT2 subclass could have the potential to limit fibrosis and restore tissue regeneration. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease. (C) 2012 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Mann DA, Oakley F

Publication type: Review

Publication status: Published

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year: 2013

Volume: 1832

Issue: 7

Pages: 905-910

Print publication date: 01/07/2013

Online publication date: 29/09/2012

Acceptance date: 22/09/2012

ISSN (print): 0925-4439

Publisher: ELSEVIER SCIENCE BV

URL: http://dx.doi.org/10.1016/j.bbadis.2012.09.009

DOI: 10.1016/j.bbadis.2012.09.009


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