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Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease

Lookup NU author(s): Eva Kenny, Professor John O'Brien, Dr Michael Firbank, Professor Andrew Blamire

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Abstract

BackgroundResting-state functional magnetic resonance imaging (fMRI) can be used to measure correlations in spontaneous low-frequency fluctuations in the blood oxygen level-dependent (BOLD) signal which represent functional connectivity between key brain areas.AimsTo investigate functional connectivity with regions hypothesised to be differentially affected in dementia with Lewy bodies (DLB) compared with Alzheimer's disease and controls.MethodFifteen participants with probable DLB, 16 with probable Alzheimer's disease and 16 controls were scanned in the resting-state using a 3T scanner. The BOLD signal time-series of fluctuations in seed regions were correlated with all other voxels to measure functional connectivity.ResultsParticipants with DLB and Alzheimer's disease showed greater caudate and thalamic connectivity compared with. controls. Those with DLB showed greater putamen connectivity compared with those with Alzheimer's disease and the controls. No regions showed less connectivity in DLB or Alzheimer's disease v. controls, or in DLB v. Alzheimer's disease.ConclusionsAltered connectivity in DLB and Alzheimer's disease provides new insights into the neurobiology of these disorders and may aid in earlier diagnosis.


Publication metadata

Author(s): Kenny ER, O'Brien JT, Firbank MJ, Blamire AM

Publication type: Article

Publication status: Published

Journal: British Journal of Psychiatry

Year: 2013

Volume: 203

Issue: 3

Pages: 209-214

Print publication date: 01/09/2013

Online publication date: 11/07/2013

Acceptance date: 03/04/2013

ISSN (print): 0007-1250

ISSN (electronic): 1472-1465

Publisher: Royal College of Psychiatrists

URL: http://dx.doi.org/10.1192/bjp.bp.112.108464

DOI: 10.1192/bjp.bp.112.108464


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