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Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy

Lookup NU author(s): Professor Andrew Blamire, Ian Wilson

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Abstract

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 angstrom from a lanthanide ion. At this distance, the resonance is shifted to a region of the H-1 NMR spectral window far away from the usual 0-12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100-200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg(-1).


Publication metadata

Author(s): Harvey P, Blamire AM, Wilson JI, Finney KLNA, Funk AM, Senanayake PK, Parker D

Publication type: Article

Publication status: Published

Journal: Chemical Science

Year: 2013

Volume: 4

Issue: 11

Pages: 4251-4258

Print publication date: 01/11/2013

Online publication date: 19/08/2013

Acceptance date: 19/08/2013

ISSN (print): 2041-6520

ISSN (electronic): 2041-6539

Publisher: RSC Publications

URL: http://dx.doi.org/10.1039/c3sc51526e

DOI: 10.1039/c3sc51526e


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