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Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

Lookup NU author(s): Professor Sir John Burn

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Abstract

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.


Publication metadata

Author(s): Vasen HFA, Blanco I, Aktan-Collan K, Gopie JP, Alonso A, Aretz S, Bernstein I, Bertario L, Burn J, Capella G, Colas C, Engel C, Frayling IM, Genuardi M, Heinimann K, Hes FJ, Hodgson SV, Karagiannis JA, Lalloo F, Lindblom A, Mecklin JP, Moller P, Myrhoj T, Nagengast FM, Parc Y, de Leon MP, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Sijmons RH, Tejpar S, Thomas HJW, Rahner N, Wijnen JT, Jarvinen HJ, Moslein G, the Mallorca Group

Publication type: Review

Publication status: Published

Journal: Gut

Year: 2013

Volume: 62

Issue: 6

Pages: 812-823

Print publication date: 01/06/2013

Online publication date: 13/02/2013

Acceptance date: 16/01/2013

ISSN (print): 0017-5749

ISSN (electronic): 1468-3288

Publisher: BMJ PUBLISHING GROUP

URL: http://dx.doi.org/10.1136/gutjnl-2012-304356

DOI: 10.1136/gutjnl-2012-304356


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