Lookup NU author(s): Dr Margaret Piggott,
Emeritus Professor Robert Perry
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Specific [H-3]nitrendipine binding which was shown to be calcium- and calmodulin-dependent was found to be significantly reduced in the temporal cortex in Alzheimer's disease compared to age-matched controls. Scatchard analysis revealed that this reduction was due to a loss in the number of cortical [H-3]nitrendipine binding sites rather than a change in the affinity of the binding site in the Alzheimer patients. The reduction in cortical [H-3]nitrendipine-specific binding was most marked in those Alzheimer's disease cases where the duration of the dementing illness was longer than two years. In contrast, no reduction in cortical [H-3]nitrendipine binding was found in Huntington's disease. There was no significant correlation found between age (38-89 years) and [H-3]nitrendipine binding in control cases, or between mean overall plaque counts and [H-3]nitrendipine binding in the Alzheimer's disease cases. There was a significant correlation found between age (46-88 years) and [H-3]nitrendipine binding in the Alzheimer's disease cases where the duration of the dementing illness was greater than two years.
Author(s): Piggott MA, Candy JM, Perry RH
Publication type: Article
Publication status: Published
Journal: Brain Research
Print publication date: 22/11/1991
ISSN (print): 0006-8993
ISSN (electronic): 1872-6240
Publisher: Elsevier BV
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