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Salvaging hope: Is increasing NAD+ a key to treating mitochondrial myopathy?

Lookup NU author(s): Professor Robert Lightowlers, Professor Zofia Chrzanowska-Lightowlers

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Abstract

Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan etal () use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.


Publication metadata

Author(s): Lightowlers RN, Chrzanowska-Lightowlers ZMA

Publication type: Article

Publication status: Published

Journal: EMBO Molecular Medicine

Year: 2014

Volume: 6

Issue: 6

Pages: 705-707

Print publication date: 16/05/2014

ISSN (print): 1757-4676

ISSN (electronic): 1757-4684

Publisher: Wiley-Blackwell Publishing

URL: http://dx.doi.org/10.15252/emmm.201404179

DOI: 10.15252/emmm.201404179


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